What video card you have? And what driver is in use? You can choose "Default" theme for cursor in Settings -> Mouse. The Pearl theme may work buggy with few drivers.
i have nvidia quadro onboard asus M2NBP-VM CSM motherboard. NVIDIA Quadro® NVS 210S+NVIDIA nForce® 430B its not the proprietary driver. its one that someone recommended on the reaper forum. nouveau drivers i think.